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Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 225-232 doi: 10.15302/J-FASE-2019265

Abstract: are reviewed and placed into the context of developments arising from the availability of the high-quality

Keywords： assembly technology     molecular markers     polyploidy     transcript networks     wheat genome    

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Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective Review

Yazhuo Li, Ying Xie, Yufei He, Wenbin Hou, Maoliang Liao, Changxiao Liu

Engineering 2019, Volume 5, Issue 5,   Pages 888-894 doi: 10.1016/j.eng.2019.01.015

Abstract: Current quality control of herbal medicines, however, is in great dispute.Unlike chemical drugs, which have clear and validated quality standards, the content of only one (ormarkers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.This work provides useful information for the quality control of herbal medicines in the future.

Keywords： Traditional Chinese medicine     Quality marker     Quality control    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: antifolate resistance levels of P. vivax parasites were different across China and molecular markers

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 411-419 doi: 10.1007/s11684-018-0659-3

Abstract: Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes associated with RA. We then systematically review various factors that have a predictive value (predictors) for the response to different drugs in RA treatment, especially recent advances. These predictors include but are certainly not limited to genetic variations, clinical factors, and demographic factors. However, no clinical application is currently available. This review also describes the challenges in treating patients with RA and the need for personalized medicine. At the end of this review, we discuss possible strategies to enhance the prediction of drug responsiveness in patients with RA.

Keywords： rheumatoid arthritis     gene     clinical markers     therapy    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic and epigenetic alterations, and leads to the activation of oncogenes and the inactivation or loss of tumor suppressor genes (TSG). In addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognized as a common molecular alteration in human tumors. In esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, but also in premalignant lesions. DNA methylation is related to survival time and sensitivity of chemoradiotherapy. This review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection for patient prognosis, treatment choices, and potential targeting therapy.

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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Exploring the diagnosis markers for gallbladder cancer based on clinical data

Lingqiang Zhang,Runchen Miao,Xiude Zhang,Wei Chen,Yanyan Zhou,Ruitao Wang,Ruiyao Zhang,Qing Pang,Xinsen Xu,Chang Liu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 350-355 doi: 10.1007/s11684-015-0402-2

Abstract:

Presently, no effective markers are available to facilitate gallbladder cancer (GBC) diagnosis.This study aims to explore available markers for GBC diagnosis.curve (AUC), 0.720], ALP (AUC, 0.713), TB (AUC, 0.636), and age (AUC, 0.573) were valuable diagnosis markers

Keywords： marker     gallbladder cancer     diagnosis    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: renal failure, whether they have had hemodialysis or not, the specificity of some of the serum tumor markersThe detection of tumor markers is extensively used for the diagnosis of corresponding tumors.It has been recently shown that some tumor markers are higher in patients with chronic kidney diseaseThe effects of renal function and hemodialysis were examined on serum levels of some of the tumor markersNine tumor markers in 37 uremic patients were tested.

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: These molecular markers in NSCLC demonstrated close associations with the development of lung cancer

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS

WU Lianhua, GAO Chunjin, WANG Guozhong, YANG Lin, HOU Xiaomin, GE Huan, XIA Chengqing, QI Man

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 410-412 doi: 10.1007/s11684-007-0080-9

Abstract: There is no significant difference (>0.05) in those markers between patients and 17 healthy adults.

Keywords： significant difference     partial thromboplastin     coagulation function     femoral     healthy    

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Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 260-265 doi: 10.15302/J-FASE-2015070

Abstract: After testing 615 SSR and STS markers covering the 12 rice chromosomes, 186 markers were selected thatMolecular markers linked to the BB resistance genes in Y73 were scanned using the F population and thepolymorphic markers.

Keywords： Oryza meyeriana     bacterial blight resistance gene     genetic population     linkage molecular marker    

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Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine Review

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Engineering 2019, Volume 5, Issue 1,   Pages 60-68 doi: 10.1016/j.eng.2018.11.008

Abstract: medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and qualitymarkers (Q markers).We also highlight the discovery of lead compounds and Q markers from TCMs.

Keywords： Chinmedomics     Serum pharmacochemistry of TCM     Efficacy     Metabolomics     Syndrome     Biomarkers     Quality markers    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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From total quality management to Quality 4.0: A systematic literature review and future research agenda

Frontiers of Engineering Management 2023, Volume 10, Issue 2,   Pages 191-205 doi: 10.1007/s42524-022-0243-z

Abstract: Quality 4.0 is an emerging concept that has been increasingly appreciated because of the intensificationIt deals with aligning quality management practices with the emergent capabilities of Industry 4.0 toimprove cost, time, and efficiency and increase product quality.concept, Quality 4.0 implementation, quality management in Quality 4.0, and Quality 4.0 model and applicationthe quality curve theory, and highlight future research opportunities.

Keywords： quality management     Quality 4.0     Industry 4.0     literature review     predictive quality    

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Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 106-110 doi: 10.1007/s11465-008-0019-0

Abstract: Enabling quality managers to utilize and manage quality data efficiently under modern quality managementcircumstances is a primary issue for improving enterprise quality management.A concept of quality metadata is proposed in this paper, which can help quality managers gain a deeperunderstanding of various features of quality data and establish a more stable foundation for furtherThe procedure of establishing quality metadata standards is emphasized in the paper, and the content

Keywords： enterprise quality     foundation     description     quality management     primary    

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Validation of

Youfen Xu, Zong Li, Ruyin Liu, Hongxia Liang, Zhisheng Yu, Hongxun Zhang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1246-9

Abstract: Pig-Bac2SYBR, Pig-1-BacTaqMan, and Pig-2-BacTaqMan, which are based on Bacteroidales 16S rRNA gene markers

Keywords： Microbial source tracking     Pig fecal pollution     16S rRNA gene markers     Pig-specific Bacteroidales    

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Title Author Date Type Operation

Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

Journal Article

Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective

Yazhuo Li, Ying Xie, Yufei He, Wenbin Hou, Maoliang Liao, Changxiao Liu

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

Exploring the diagnosis markers for gallbladder cancer based on clinical data

Lingqiang Zhang,Runchen Miao,Xiude Zhang,Wei Chen,Yanyan Zhou,Ruitao Wang,Ruiyao Zhang,Qing Pang,Xinsen Xu,Chang Liu

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS

WU Lianhua, GAO Chunjin, WANG Guozhong, YANG Lin, HOU Xiaomin, GE Huan, XIA Chengqing, QI Man

Journal Article

Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

Journal Article

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

From total quality management to Quality 4.0: A systematic literature review and future research agenda

Journal Article

Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

Journal Article

Validation of

Youfen Xu, Zong Li, Ruyin Liu, Hongxia Liang, Zhisheng Yu, Hongxun Zhang

Journal Article